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KMID : 1144820210270040231
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대한의생명과학회지
2021 Volume.27 No. 4 p.231 ~ p.238
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Synthesis of Tetrapeptide Derived from Skin Structural Protein Sequence and Identification of Skin Anti-aging Effect
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Kang Sang-Moon
Joun Yong-Seung
Lee Kee-Young
Kang Hyun
Lee Sung-Gyu
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Abstract
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Several structural proteins present in keratinocytes of the skin are known to play an important role in the formation of epidermal tissue and barrier function, and the absence of structural proteins in keratinocytes causes various skin diseases. In this study, 42 types of tetrapeptides derived from the sequence of Loricrin, a kind of terminally differentiating structural protein, were synthesized, and skin anti-aging properties were measured by measuring the elastase inhibition, proliferation of skin cells. The anti-aging efficacy was verified and, based on this, it succeeded in selecting one of the most excellent peptides. It is expected that the selected tetrapeptide can be used as a raw material for various cosmetics and quasi-drugs based on anti-aging and skin cell proliferation effects.
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KEYWORD
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Loricrin, Tetrapeptide, Peptide synthesis, Anti-oxidant, Cell proliferation
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